Glucosamine Sulfate is a stable, clinically-studied form of glucosamine, which is the fundamental building block required for the synthesis of connective tissue subunits (glycosaminoglycans). Glucosamine is an essential building block of proteoglycans, hyaluronic acid (a component of joint lubrication) and glycolipids, and it is essential for the proper formation of tendons, ligaments, synovial fluid, bones, skin, nails, and blood vessels.* OsteoBiMax® glucosamine is naturally water-soluble, and low in molecular weight, thereby offering rapid and high absorption (over 90%). MSM is a sulfur donor which is essential for the formation of chondroitin sulfates. Vitamin C and manganese are required for synthesis of collagen and cartilage. People with osteoarthritis are often deficient in Vitamin D3.